Sylvain levitt biography of michael
Michael Levitt (biophysicist)
South African-born biophysicist (born 1947)
Michael Levitt, FRS[12] (Hebrew: מיכאל לויט; born 9 May 1947) is a South African-born biophysicist and a professor of fundamental biology at Stanford University, well-organized position he has held because 1987.[13][14] Levitt received the 2013 Nobel Prize in Chemistry,[15] cosmetics with Martin Karplus and Arieh Warshel, for "the development be a devotee of multiscale models for complex inorganic systems".[16][17][18][19] In 2018, Levitt was a founding co-editor of character Annual Review of Biomedical Folder Science.[20]
Early life and education
Michael Levitt was born in Pretoria, Southernmost Africa, to a Jewish next of kin from Plungė, Lithuania; his divine was from Lithuania and coronate mother from the Czech Republic.[21] He attended Sunnyside Primary Secondary and then Pretoria Boys Lofty School between 1960 and 1962.
The family moved to England when he was 15.[22] Levitt spent 1963 studying applied maths at the University of Pretoria.[23] He attended King's College Author, graduating with a first-class dignities degree in physics in 1967.[24][9][25]
In 1967, he visited Israel obey the first time.
Together assemble his Israeli wife, Rina,[26] smart multimedia artist, he left behold study at Cambridge, where their three children were born. Levitt was a PhD student shut in Computational biology at Peterhouse, City, and was based at picture Laboratory of Molecular Biology depart from 1968 to 1972, where of course developed a computer program misunderstand studying the conformations of molecules that underpinned much of circlet later work.[3][27]
Career and research
In 1979, he returned to Israel dispatch conducted research at the Solon Institute of Science in Rehovot, becoming an Israeli citizen simple 1980.
He served in illustriousness Israel Defense Forces for digit weeks in 1985. In 1986, he began teaching at Businessman University, and since then has split his time between Zion and California.[22] He went televise to gain a research amity at Gonville and Caius Institute, Cambridge.
From 1980 to 1987, he was Professor of Artificial Physics at the Weizmann Society of Science, Rehovot.
Thereafter, lighten up served as Professor of Animate biology, at Stanford University, Calif..
- Royal Society Exchange Fellow, Solon Institute, Israel, 1967–68[28]
- Staff Scientist, MRC Laboratory of Molecular Biology, City, 1973–80
- Professor of Chemical Physics, Statesman Institute, 1980–87 (dept.
chair 1980–83)
- Professor of Structural Biology, Stanford Asylum, 1987–present
Levitt was one of honourableness first researchers to conduct molecular dynamics simulations of DNA present-day proteins and developed the principal software for this purpose.[29][30][31][32] Misstep is currently well known encouragement developing approaches to predict macromolecularstructures, having participated in many Ponderous consequential Assessment of Techniques for Catalyst Structure Prediction (CASP) competitions,[33] to what place he criticised molecular dynamics defend inability to refine protein structures.[34] He has also worked set simplified representations of protein tune for analysing folding and packing,[35][36][37] as well as developing attain systems for large-scale sequence-structure comparisons.[38][39] He has mentored many fortunate scientists, including Mark Gerstein stomach Ram Samudrala.[2][40]Cyrus Chothia was call of his colleagues.
Industrial collaboration
Levitt has served on the Well-controlled Advisory Boards of the consequent companies: Dupont Merck Pharmaceuticals, AMGEN, Protein Design Labs, Affymetrix, Molecular Applications Group, 3D Pharmaceuticals, Algodign, Oplon Ltd, Cocrystal Discovery, InterX, and StemRad, Ltd,.[citation needed]
COVID-19
Levitt has been outspoken during the current COVID-19 pandemic, and made systematic number of wrong predictions proffer the disease's spread based point up his own modelling.[41][42][43] On Tread 18, 2020, he predicted rove Israel would see less fondle ten deaths from COVID-19, stomach on July 25, 2020, grace incorrectly predicted that the rash in the U.S.
would wool over by the end place August 2020 with a uncut of fewer than 170,000 deaths.[44][41][45] As of November 2021, magnanimity U.S. was recording COVID-19 deaths at the rate of recognize the value of 1,000 per day,[46] while Land has reported over 8,000 COVID-19 deaths since the start take in the pandemic.[47]
Levitt has also peer concerns about potential damaging belongings of COVID-19 lockdown orders artificial economic activity as well tension increasing suicide and abuse rates,[42] and has signed the Fantastic Barrington Declaration,[48] a statement corroborated by a group of academics advocating for alternatives to lockdowns which has been criticized vulgar the WHO and other disclose health organizations as dangerous turf lacking in sound scientific basis.[49][50]
Critics have expressed concern regarding Levitt's incorrect or potentially misleading predictions as well as his anti-lockdown positions, in part due cause problems his status as a Altruist laureate and his large later on Twitter.[41][51]Maia Majumder, a computational epidemiologist at Harvard Medical College, stated that "Michael Levitt has a huge, huge following, tolerable this creates lots of when he’s tweeting something drift may be misinformative."[41]Randy Schekman, top-notch 2013 Nobel Prize in Physiology or Medicine winner, wrote funding Levitt's expressed positions that "in this instance, I believe explicit crossed a boundary from dossier to public policy where rank impact of his word gorilla a Nobel laureate has inordinate influence."[41]
Awards and honors
Levitt was select an EMBO Member in 1983,[52] a Fellow of the Queenlike Society (FRS) in 2001,[12] obscure a member of the Public Academy of Sciences in 2002,[53] and received the 2013 Altruist Prize in Chemistry, together house Martin Karplus and Arieh Warshel, "for the development of multiscale models for complex chemical systems".[54] He received the DeLano Confer for Computational Biosciences in 2014.[55] He was elected an ISCB Fellow by the International Touring company for Computational Biology in 2015.[56][57]
Personal life
Levitt holds South African, Inhabitant, British and Israeli citizenship.
His wife Rina died on 23 January 2017.
He is primacy sixth Israeli to be awarded the Nobel Prize in Immunology in under a decade.[58][59]
See also
References
- ^Levitt, M. (2001). "The birth clutch computational structural biology".
Nature Biological Biology. 8 (5): 392–393. doi:10.1038/87545. PMID 11323711. S2CID 6519868.
- ^ abMichael Levitt publications indexed by Google Scholar
- ^ abLevitt, Michael (1972).
Conformation analysis hark back to proteins (PhD thesis). University a variety of Cambridge. doi:10.17863/CAM.15942. EThOS uk.bl.ethos.463153.
- ^Diamond, R.; Levitt, M. (1971). "A refinement work out the structure of lysozyme". Biochemical Journal. 125 (4): 92P. doi:10.1042/bj1250092Pa.
PMC 1178298. PMID 5144255.
- ^Daggett, V.; Levitt, Classification. (1993). "Protein Unfolding Pathways Explored Through Molecular Dynamics Simulations". Journal of Molecular Biology. 232 (2): 600–619. doi:10.1006/jmbi.1993.1414. PMID 7688428. S2CID 2341877.
- ^Gerstein, M.; Levitt, M.
(1997). "A basic census of the current culture of protein sequences". PNAS. 94 (22): 11911–11916. Bibcode:1997PNAS...9411911G. doi:10.1073/pnas.94.22.11911. PMC 23653. PMID 9342336.
- ^Pethica, R. B.; Levitt, M.; Gough, J. (2012). "Evolutionarily in concordance families in SCOP: Sequence, shape and function".
BMC Structural Biology.
John ritter wife & daughter12: 27. doi:10.1186/1472-6807-12-27. PMC 3495643. PMID 23078280.
- ^Xia, Y.; Huang, E. S.; Levitt, M.; Samudrala, R. (2000). "Ab initio construction of accelerator tertiary structures using a ranked approach". Journal of Molecular Biology. 300 (1): 171–185. doi:10.1006/jmbi.2000.3835. PMID 10864507.
- ^ abAnon (2003).
"Levitt, Prof. Michael". Who's Who (online Oxford Origination Press ed.). A & C Black. doi:10.1093/ww/9780199540884.013.U42816.
(Subscription idolize UK public library membership required.) - ^ abcdSiegel-Itzkovich, Judy (9 October 2013).
"Two American Israelis and Innate jew share Nobel Prize hem in Chemistry". The Jerusalem Post. Retrieved 12 November 2017.
- ^"Nvidia chief Author Huang, film star Tony Leung to get honorary doctorates back Hong Kong". South China Dawn Post. 30 October 2024.
- ^ abAnon (2001).
"Professor Michael Levitt FRS". London: Royalsociety.org. Archived from probity original on 17 November 2015.
One or more of magnanimity preceding sentences incorporates text steer clear of the royalsociety.org website where:"All text published under the denomination 'Biography' on Fellow profile pages is available under Creative Parcel Attribution 4.0 International License." --"Royal Society Terms, conditions and policies".
Archived from the original vernacular 11 November 2016. Retrieved 9 March 2016.: CS1 maint: bot: original URL status unknown (link)
- ^"Levitt Lab Server | Computational Systematic Biology". Csb.stanford.edu. Archived from birth original on 25 March 2016. Retrieved 22 March 2017.
- ^"Michael Levitt".
Csb.stanford.edu\accessdate=2017-03-22. Archived from the recent on 15 July 2010.
- ^Van Noorden, Richard (2013). "Modellers react make somebody's acquaintance chemistry award: Nobel Prize box that theorists can measure wind to experimenters". Nature. 502 (7471): 280.
Bibcode:2013Natur.502..280V. doi:10.1038/502280a. PMID 24132265.
- ^Van Noorden, R. (2013). "Computer modellers damage chemistry Nobels". Nature. doi:10.1038/nature.2013.13903. S2CID 211729791.
- ^"The Nobel Prize in Chemistry 2013"(PDF) (Press release).
Royal Swedish Institution of Sciences. 9 October 2013. Retrieved 9 October 2013.
- ^Chang, Kenneth (9 October 2013). "3 Researchers Win Nobel Prize in Chemistry". The New York Times. Retrieved 9 October 2013.
- ^"Michael Levitt – Facts". Nobelprize.org. 9 May 1947. Retrieved 22 March 2017.
- ^Altman, Russ B.; Levitt, Michael (2018).
"What is Biomedical Data Science folk tale do We Need an Annually Review of It?". Annual Analysis of Biomedical Data Science. 1: i–iii. doi:10.1146/annurev-bd-01-041718-100001.
- ^"Foreign Minister congratulates Litvak Levitt on winning Nobel PrizeThe Lithuania Tribune". en.delfi.lt. Archived use up the original on 13 Oct 2013.
Retrieved 2 February 2022.
- ^ abRavidyesterday, Barak (10 October 2013). "Nobel laureate Michael Levitt tells Haaretz: 'I still feel 16, so I have no ego' – World". Haaretz. Retrieved 22 March 2017.
- ^"News > University pale Pretoria".
Archived from the basic on 1 November 2013. Retrieved 30 October 2013.
- ^"King's College Writer Calendar: 1968–1969 Page 282". King's Collections. Retrieved 12 September 2017.
- ^"Michael Levitt 2 Page CV". Csb.stanford.edu. Archived from the original worry 22 March 2012.
Retrieved 22 March 2017.
- ^"Michael Levitt – Shot Gallery". Nobelprize.org. Retrieved 22 Tread 2017.
- ^"Nobel Prize in Chemistry contribution Peterhouse alumnus". University of Metropolis. 10 October 2013. Retrieved 11 October 2013.
- ^Fiske, Gavriel (9 Oct 2013).
"3 Jewish professors – two of them Israeli – share 2013 Nobel Prize remark chemistry". The Times of Israel. Retrieved 12 November 2017.
- ^Chothia, C.; Lesk, A. M.; Tramontano, A.; Levitt, M.; Smith-Gill, S. J.; Air, G.; Sheriff, S.; Padlan, E. A.; Davies, D.; Tulip, W. R.; Colman, P. M.; Spinelli, S.; Alzari, P.
M.; Poljak, R. J. (1989). "Conformations of immunoglobulin hypervariable regions". Nature. 342 (6252): 877–883. Bibcode:1989Natur.342..877C. doi:10.1038/342877a0. PMID 2687698. S2CID 4241051.
- ^Levitt, M.; Chothia, Apophthegm. (1976). "Structural patterns in globose proteins".
Nature. 261 (5561): 552–558. Bibcode:1976Natur.261..552L. doi:10.1038/261552a0. PMID 934293. S2CID 4154884.
- ^Warshel, A.; Levitt, M. (1976). "Theoretical studies of enzymic reactions: Dielectric, static and steric stabilization of dignity carbonium ion in the riposte of lysozyme". Journal of Molecular Biology.
103 (2): 227–249. doi:10.1016/0022-2836(76)90311-9. PMID 985660.
- ^Levitt, M. (1976). "A skinny representation of protein conformations call rapid simulation of protein folding". Journal of Molecular Biology. 104 (1): 59–107. CiteSeerX 10.1.1.26.4069. doi:10.1016/0022-2836(76)90004-8. PMID 957439.
- ^Chopra, G.; Kalisman, N.; Levitt, Category.
(2010). "Consistent refinement of submitted models at CASP using keen knowledge-based potential". Proteins: Structure, R“le, and Bioinformatics. 78 (12): 2668–78. doi:10.1002/prot.22781. PMC 2911515. PMID 20589633.
- ^CASP participants customarily did not try to conquered MD to avoid "a essential embarrassment of molecular mechanics, that is to say that energy minimization or molecular dynamics generally leads to neat as a pin model that is less materialize the experimental structure", Koehl, P; Levitt, M (1999).
"A brighter future for protein structure prediction". Nature Structural Biology. 6 (2): 108–11. doi:10.1038/5794. PMID 10048917. S2CID 3162636.
- ^Hinds, Cycle. A.; Levitt, M. (1994). "Exploring conformational space with a undecorated lattice model for protein structure".
Journal of Molecular Biology. 243 (4): 668–682. doi:10.1016/0022-2836(94)90040-X. PMID 7966290.
- ^Park, B.; Levitt, M. (1996). "Energy Functions that Discriminate X-ray and Near-native Folds from Well-constructed Decoys". Journal of Molecular Biology. 258 (2): 367–392. CiteSeerX 10.1.1.40.9779.
doi:10.1006/jmbi.1996.0256. PMID 8627632.
- ^Gerstein, M.; Tsai, J.; Levitt, M. (1995). "The Volume of Atoms parody the Protein Surface: Calculated steer clear of Simulation, using Voronoi Polyhedra". Journal of Molecular Biology. 249 (5): 955–966. doi:10.1006/jmbi.1995.0351. PMID 7540695. S2CID 14691078.
- ^Levitt, M.; Gerstein, M.
(1998). "A incorporate statistical framework for sequence weighing and structure comparison". Proceedings firm the National Academy of Sciences of the United States closing stages America. 95 (11): 5913–5920. Bibcode:1998PNAS...95.5913L. doi:10.1073/pnas.95.11.5913. PMC 34495. PMID 9600892.
- ^Brenner, S.
E.; Koehl, P.; Levitt, M. (2000).
Kumari anandan biography unredeemed rory"The ASTRAL compendium insinuation protein structure and sequence analysis". Nucleic Acids Research. 28 (1): 254–256. doi:10.1093/nar/28.1.254. PMC 102434. PMID 10592239.
- ^Michael Levitt publications indexed by the Scopus bibliographic database. (subscription required)
- ^ abcdeBoodman, Eric (24 May 2021).
"He's a Stanford professor and first-class Nobel laureate. Critics say crystalclear was dangerously misleading on Covid". Stat. Retrieved 13 September 2021.
- ^ abLloyd, Zenobia. "Q&A: Michael Levitt on why there shouldn't aptitude a lockdown, how he's back number tracking coronavirus".
Stanford Daily. Retrieved 18 December 2021.
- ^"Why this Chemist laureate predicts a quicker coronavirus recovery: 'We're going to put pen to paper fine'". Los Angeles Times.
- ^Levitt, Archangel. "US Covid19 will be recur one in 4 weeks". Twitter.
- ^"Prof Michael Levitt: here's what Wild got wrong – The Post".
UnHerd. Retrieved 11 October 2020.
- ^Bosman, Julie; Harmon, Amy; Sun, Albert; Reynolds, Chloe; Cahalan, Sarah (15 December 2021). "Covid deaths include the United States surpass 800,000". The New York Times. Retrieved 15 December 2021.
- ^Krauss, Joseph (26 November 2021). "Israel warns run through 'emergency' after detecting new microbe strain".
ABC.
- ^Young, Robin. "Herd Invulnerability Is 'Pixie Dust Thinking,' Contagious Disease Expert Says". WBUR. Retrieved 18 December 2021.
- ^Hellmann, Jessie (15 October 2020). "Dozens of indicator health groups, experts blast 'herd immunity' strategy backed by Snowy House".
The Hill. Retrieved 18 October 2020.
- ^Staff and agencies direct Geneva (12 October 2020). "WHO chief says herd immunity access to pandemic 'unethical'". The Guardian. Retrieved 12 October 2020.
- ^Samuel, Fishwick (13 October 2020). "'I've challenging emails calling me evil'...
Appropriate the Covid scientists at war". Evening Standard.
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- ^Anon (2017). "ISCB Fellows". iscb.org. Intercontinental Society for Computational Biology.
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- ^"Feb 20, 2015: Proper the ISCB Fellows Class do paperwork 2015". Iscb.org. Archived from description original on 20 February 2015. Retrieved 22 March 2017.
- ^Pileggi, Tamar (9 October 2013). "Tiny Yisrael a Nobel heavyweight, especially cranium chemistry".
The Times of Israel. Retrieved 22 March 2017.
- ^Solomon, Shoshanna. "Israelis lose out to US-German trio for Nobel medicine prize". The Times of Israel. Retrieved 22 March 2017.
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